Gifford Bioscience Limited (previously Invivopharm Inc.) is a preclinical contract research organization (CRO) providing pharmacology services in the area of radiometric receptor binding and receptor occupancy studies.
Determination of IC50 and Ki values for receptor-drug competitive interactions in a tissue homogenate, cells or immobilized receptors.
Determination of uptake and release processes and receptor binding assays in cell cultures.
Measurement of the degree to which the test compound engages its target receptor in the animal. Receptor occupancy is determined by competition of the compound with binding of a radiotracer to the receptor.
Imaging the receptor binding and distribution of radioactivity in a tissue or organ section following incubation with the radiolabeled drug.
Radioiodine labeling of antibodies and proteins and tritium labeling of small molecules. Compounds are labeled to a sufficient specific activity for use in our in vitro and in vivo receptor binding and occupancy studies.